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This Week in Psychiatry — 5/9/11

May 10, 2011

Psychosis and Substance Abuse are Possible Risk Factors for Osteoporosis

Psychosis and substance abuse are possible risk factors for osteoporosis, yet the frequency of screening and disease risk as relatively unknown. Research published in Osteoporois International studied 18,593 women between 50—64 years of age. Of these women, 6.7% had osteoporosis. Women diagnosed with both substance use disorder and psychosis were found to have a higher prevalence of osteoporosis (OR=6.4 CI=1.51-27.6, P=.012). This interaction was also more prevalent in the patients between 55–64 years of age compared to those between 50–54 years of age

Psychiatric Disorder Risks and Paternal Age 

A Dutch population study, published in Schizophrenia Research, analyzed 14,231 patients and 56,924 matched controls for an association between paternal age and risk of psychiatric disorders, such as autism spectrum disorders, major depression, bipolar disorder, and schizophrenia. Using logistic regression, the authors found that older fathers (>40 years of age) have a 3.3 times increased odds of having a child with autism spectrum disorders compared to fathers <20 years of age. Schizophrenia was associated with fathers aged >35 years (OR=1.27, 95% CI: 1.05-1.53), major depression was associated with younger and older fathers, and there was no association between paternal age and bipolar disorder

Secondhand Smoke Exposure: Effects on Nicotine Receptor Occupancy in Smokers and Nonsmokers

Researchers used PET scanning and radiotracers to determine the effects of secondhand smoke on brain α4ß2* nicotinic acetylcholine receptor occupancy. The study, published in the Archives of General Psychiatry, included 24 young adults (11 moderately dependent cigarette smokers, 13 nonsmokers) who underwent PET scanning during 1 hour of moderate exposure or no exposure, respectively, to secondhand smoke in an environment resembling an automobile’s front passenger seat. Secondhand smoke exposure caused a mean 19% occupancy of α4ß2* nAChRs occupancy. Smokers had a 23% increase in craving with secondhand smoke exposure, as well.

“This Week in Psychiatry” is written Christopher Naccari and Lonnie Stoltzfoos

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